Absolute cross-sections for DNA strand breaks and crosslinks induced by low energy electrons

How do low-energy (0.1-2 eV) electrons cause DNA-strand breaks?

We overview our recent theoretical predictions and the innovative experimental findings that inspired us concerning the mechanisms by which very low-energy (0.1-2 eV) free electrons attach to DNA and cause strong (ca. 4 eV) covalent bonds to break causing so-called single-strand breaks. Our primary conclusions are that (i) attachment of electrons in the above energy range to base pi* orbitals i...

DNA strand breaks induced by 0-4 eV electrons: the role of shape resonances.

Collisions of 0-4 eV electrons with thin DNA films are shown to produce single strand breaks. The yield is sharply structured as a function of electron energy and indicates the involvement of pi* shape resonances in the bond breaking process. The cross sections are comparable in magnitude to those observed in other compounds in the gas phase in which pi* electrons are transferred through the mo...

DNA Radiosensitization: The Search for Repair Refractive Lesions Including Double Strand Breaks and Interstrand Crosslinks

Simulation of strand breaks induced in DNA molecule by radiation of proton and Secondary particles using Geant4 code

Radiotherapy using various beams is one of the methods for treating cancer, Hadrons  used   to  treat cancers  that  are  near critical organs. The most important part of the cell that is damage by ionizing radiation is DNA. In this study, damages induced in the  genetic material of  living cells (DNA) defined by  the  atomic model from the  protein data bank (PDB) have been studied by  radiati...

DNA Double-Strand Breaks

The activation-induced cytidine deaminase (AID) is required for somatic hypermutation (SHM) and class-switch recombination (CSR) of immunoglobulin (Ig) genes, both of which are associated with DNA double-strand breaks (DSBs). As AID is capable of deaminating deoxy-cytidine (dC) to deoxy-uracil (dU), it might induce nicks (single strand DNA breaks) and also DNA DSBs via a U-DNA glycosylase-media...